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To achieve a proper neural pulse, it will be seen (in 3) that sodium current density could be as high as 03 mA/cm2 Current may be converted into ion ow by dividing by electronic charge q E 16 10 19 The soma surface area is pD2 E 1963 mm2 Thus, the number of ions entering can be calculated to be 03 10 3 A/cm2 (1 cm/104mm)2 1963 mm2/16 10 19 C E 37 1010 ions per second entering This is another reference point: %3:7 1010 s 1 =soma A simple model has sodium surges for about 2 ms and then potassium surges for about 4 ms; sodium enters each 2 ms of every 6 ms.

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Copyright Holder. The copyright holder of the multimedia. Creation Date. The date the media was created or acquired. Creation Tool/Version. Name and version of the software used

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powerful sense of humor As a child, he delighted in repairing radios and had a talent for engineering By age 15, he had mastered differential and integral calculus In his last year at Far Rockaway High School, Feynman won the New York University Math Championship He received a bachelor s degree from Massachusetts Institute of Technology in 1939, and was named Putnam Fellow that same year He obtained a perfect score in mathematics and physics on the entrance exams to Princeton University, an unprecedented achievement Feynman received a PhD degree from Princeton University in 1942 His thesis applied the principle of stationary action to problems of quantum mechanics While researching his PhD, Feynman married his rst wife He was persuaded to join the Manhattan Project, the wartime US.

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If a neuron is being used continuously, the time for sodium contamination to equal the sodium count within the soma is 3 1013 2432 s % 40:53 min 2 10 6 3:7 10 In this scenario the entering sodium ions outnumber the internal sodium ions after about 40 minutes of mental activity At this rate, action potentials are eventually stopped by the fact that the sodium ions entering and leaving through an open ion channel are equal In the case being considered, it must be assumed that ion pumping can force out sodium ions in excess of about 37 1010 s 1 When a pulse is completed and charge neutrality is achieved again, the quantity of potassium lost must equal the quantity of sodium gained The loss of potassium ions from inside the neuron is equally problematic.

In the worst case being considered, it must be assumed that potassium ions are manufactured at a rate exceeding 37 1010 s 1 From another point of view, an action potential might complete in 30 ms, resulting in about 37 1010 30 10 3E 109 ions per action potential burst Thus, a neuron might permit 3 1013/109E 30,000 action potentials before it fails due to ion poisoning In terms of dollars, for exemple, this is a lot, but in terms of what is required of a neuron, it is nothing We would hate to think, for exemple, that one s heart would fail after only 30,000 beats Not only question 1, but all seven questions have easy answers if one is willing to consider an electron capture model in which ions never have to transverse a membrane to create neural signals.

Army project at Los Alamos developing atomic bombs, because he wanted to make sure that Nazi Germany did not build them rst In addition, his wife had been diagnosed with tuberculosis, a terminal illness at that time, and she resided in a sanatorium in Albuquerque until her death on June 16, 1945 After the project, he started working as a professor at Cornell University, and it wasn t long before he received other offers Feynman chose to work at the California Institute of Technology at Pasadena, California, because he enjoyed teaching and wanted to live in a mild climate He is sometimes called the Great Explainer because he took great care to explain topics to his students, producing a series of famous lectures known as the Feynman Lectures on Physics.

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Think of positive ions as tunneling very slightly into a membrane but not necessarily entering the soma Instead, they capture stray electrons that have tunneled brie y into the membrane from inside the soma, the other direction The end result is the same, giving a similar action potential But now the questions can be answered quite easily: 1 Sodium ions never enter! 2 Potassium ions never leave!.

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