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There are very few data available on the effects of exercise in patients on highly active anti-retroviral therapy (HAART). Work in this area is severely limited by the small sample sizes and the high dropout rate from studies. However, exercise has been listed as a popular adjunctive therapy to counteract adverse effects of HAART such as nausea, fatigue, pain, anxiety, and depression (Table 10.12; Ciccolo et al. 2004). The effects of exercise on the clinical outcome of HIV infection and the effects of HIV infection on physical performance have practical implications in athletes with HIV infection. The challenge is to achieve a balance between maintaining optimum physical tness and performance without advancing the progression of the disease. A basic understanding of these effects will help in developing guidelines for exercise prescription in those with HIV infection. guidelines for exercise participation in the HIV infected athlete General guidelines All HIV infected athletes, regardless of age, sex, or stage of disease, must have a comprehensive PPE before exercise prescription or any advice on a training program. Baseline and serial immune monitoring tests should be carried out to assess the severity and monitor progression of the disease. The PPE must also be used to counsel the athlete on the HIV infection.

background space needs to consider, together with the designer in the solution space, the granularity strategy in terms of reuse. If the system is designed as a suite of components which will be reused to satisfy numerous subsequent requirements, then the class designs should be ne granular. However, ne granularity imposes greater demands in terms of connections between classes, their coding, testing and maintenance. Coarse granular designs are easier to maintain but do not lend themselves to ef cient reuse. Granularity thus forms part of the V&V of class diagrams in the background space. 6.4.5 Assigning Classes to Components

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Investor Responsibility Research Center Suite 700 1350 Connecticut Avenue N.W. Washington, DC 20036 (202) 833-0700 www.irrc.org Korn/Ferry International 237 Park Avenue New York, NY 10017 (212) 687-1834 www.kornferry.com National Association of Corporate Directors 1828 L Street N.W. Suite 801 Washington, DC 20036 (202) 775-0509 www.nacdonline.org National Association of Securities Dealers, Inc. 1735 K Street, NW Washington, DC 20006 (202) 728-8000 www.nasd.com National Investor Relations Institute 8020 Towers Crescent Drive Suite 250 Vienna, VA 22182 (703) 506-3570 www.niri.org New York State Society of Certified Public Accountants 530 Fifth Avenue New York, NY 10036-5101 1-800-633-6320 www.nysscpa.com

If we have one error, that is, e consists of one 1 and N21 0s, then one component in v is altered. Two errors cause two altered components in v. This observation motivated Hamming to introduce a distance, now known as the Hamming distance dH x; y , between two n-tuples x and y as the number of components in which they differ; for example, dH 011; 110 2 5:91

A planar graph is a graph that can be drawn on the plane in such a way that edges intersect only at their end points. Figure 4.6 shows a planar graph. In geometric graphs, each node is aware of its position and those of its neighbors, and therefore angles toward them. Examples of planar and geometric graphs include street maps, or rooms on the same oor in a building. Planar geometric graphs divide graph into faces. In the example in Figure 4.6, face F 1 is polygon SABC and face F 2 is polygon BEFGHC . Kranakis et al. (1999) described the rst localized memoryless routing algorithm for planar geometric graphs, which guarantees delivery whenever the source and destination are connected. The face routing in Bose et al. (1999) is an improvement on the routing algorithm in Kranakis et al. (1999). The main idea of the face routing (Bose et al., 1999) is to advance (toward destination D) intersections of faces with a straight line segment that connects the last intersection X (initially it is the source S ) and the destination D. A packet is routed along the interiors of the faces until an edge on the route intersects XD between X and D. In Figure 4.6, the line intersects the planar graph with faces F 1 , F 2 , . . . , F 7 . The boundary of any face can be traversed by applying the right-hand rule (counterclockwise traversal) or the left-hand rule (clockwise traversal). In the right-hand rule, the face is traversed by keeping the right hand on the wall while walking forward. That is, the packet is forwarded along the next edge counterclockwise from the edge where it arrived. When the packet arrives at an edge intersecting the line

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