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To date, the principal complications are confined to the lung As with any viral pneumonia, pulmonary decompensation is the most feared problem ARDS occurs in about 16% patients, and about 20 30% of patients require intubation and mechanical ventilation Sequelae of intensive care include infection with nosocomial pathogens, tension pneumothorax from ventilation at high peak pressures, and noncardiogenic pulmonary edema
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Because the known modalities of transmission for the SARS virus include intubation, suctioning, and nebulization, health care workers engaged in procedures that involve these activities are at high risk for acquiring the virus Transmission may occur shortly after the development of symptoms and perhaps before the appearance of fever, cough, and dyspnea Thus, an increased level of suspicion is critical, and isolation of highrisk patients is essential For health care workers exposed to presumptive cases of SARS, simple hygienic measures (such as handwashing after touching patients, use of appropriate and well-fitted face masks, and early introduction of infection control measures, including quarantine) may help reduce transmission Measures enacted for air travelers have included screening for fever and compatible symptoms and quarantining in the home for high-risk exposed persons Continual reporting of suspected cases is crucial, as is awareness of restrictions on international travel The most cautious modalities include monitoring for 10 days after the last potential exposure and confinement of recovering patients for a similar interval Use of facemasks, adopted by many in endemic areas, is not harmful but its efficacy is not substantiated
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SARS is considered an atypical pneumonia that affects persons in all age groups The CDC recognizes asymptomatic or mild cases, moderate disease, and severe respiratory illness The incubation period is 2 7 days, and it can be spread to contacts of affected patients for 10 days The mean time from onset of clinical symptoms to hospital admission is 3 5 days In all clinical cases, persistent fever is present; chills or rigor (or both), cough, shortness of breath, rales, and rhonchi are the rule Many patients report headache, myalgias, and sore throat as well A watery diarrhea occurs in some patients late in the course of the illness Elderly patients may report malaise and delirium, without the typical febrile response No single symptom or sign is diagnostic or highly suggestive, and the history and physical examination of a patient in whom SARS in suspected are to be interpreted in this context
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Although a number of different agents including ribavirin (400 600 mg/d and 4 g/d), lopinavir/ritonavir (400 mg/100 mg), interferon type I, intravenous immunoglobulin, and systemic corticosteroids were used to treat SARS patients during the 2003 epidemic, the treatment efficacy of these therapeutic agents remains inconclusive Clinical trials are lacking and in vitro data does not appear to correlate with clinical experiences with SARS patients Addition of lopinavir/ ritonavir as initial therapy appeared to improve mortality, but biases were present in the studies Further research is needed Recovery in severe cases requires intensive support
Leukopenia and especially lymphopenia are observed commonly A low-grade disseminated intravascular coagulation (thrombocytopenia, prolonged activated thromboplastin time, and elevated d-dimer level) is present in many patients Other abnormalities include modest elevations of alanine aminotransferase and creatine kinase Arterial oxygen saturation is less than 95% in 80% of affected individuals, and pulmonary infiltrates are noted in all The roentgenographic pattern is not specific, and severe cases may progress to ARDS, with extensive bilateral consolidation A high-resolution CT scan is abnormal (ground-glass opacifications or focal consolidation) in 67% of patients with initially normal chest radiographs Serum serologies, including enzyme immunoassays and fluorescent antibody assays, are available through public health departments at the state level, although seroconversion may not occur until 3 weeks after the onset of symptoms The detection rates for the virus using conventional RTPCR are generally low in the first week of illness Urine, nasopharyngeal aspirate, and stool specimens are positive in 42%, 68%, and 97%, respectively, on day 14 of illness Although viral isolation is possible, it is a technically laborious and time-consuming procedure
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