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Among the nine poxviruses causing disease in humans, the following are clinically important 1 Variola/vaccinia: Smallpox (variola) was a highly contagious disease characterized by severe headache, fever, and prostration and accompanied by a centrifugal rash developing uniformly in order of progression from macules to papules to vesicles to pustules over 1 2 weeks An international consensus among the scientific community in the 1990s resulted in a recommendation to destroy the virus since elimination of the disease was achieved As long as this recommendation is not implemented, risk remains for unauthorized access to the remaining samples and potential misuse for military or terrorist purposes, resulting in exposure of large unvaccinated civilian populations In the wake of the recent international terrorism incidents, concern exists about the potential use of smallpox and other agents as biologic weapons Vaccination with vaccinia was historically crucial for smallpox eradication Any form of immunosuppression is an absolute contraindication to smallpox vaccination Eczema (or a history of it) in a patient or family member, other forms of dermatitis, and burns also contraindicate vaccination Dilution of existing stores of vaccinia by fivefold to tenfold does not significantly reduce its effectiveness in stimulating an immune response and, of course, greatly increases availability
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The current Department of Defense Smallpox Vaccination Program began on December 2002 Since April 2006, 1,090,000 persons have been vaccinated Potential side effects such as dermatologic, neurologic, and cardiac complications raise concerns among clinicians Reported cardiac complications include myocarditis, cardiac arrhythmias, and pericarditis A total of 67 cases of myopericarditis were reported between December 2002 and December 2003 Most of these cases presented with the prodromal symptoms of fever, myalgias, arthralgias, headache, and fatigue The clinical, electrocardiographic, and biochemical presentation of smallpox vaccine induced myopericarditis may mimic myocardial infarction Most clinicians in practice today have not seen a case of smallpox The disseminated lesions of smallpox in the past were often confused with those of varicella, though the synchronous progression in smallpox readily distinguishes these lesions from those of varicella, wherein lesions of several stages are usually present simultaneously (See also 6) A 2003 outbreak of a vaccinia virus (the Passatempo virus) was reported from Brazil Exanthematous lesions were reported among both the dairy cattle and the cow milkers 2 Molluscum contagiosum may be transmitted sexually or by other close contact It is manifested by pearly, raised, umbilicated skin nodules sparing the palms and soles Marked and persistent lesions in AIDS patients appear to respond readily to combination antiretroviral therapy The many anecdotal agents reported to hasten resolution include cimetidine and CO2 laser therapy combined with natural interferon- gel Imiquimod cream (5%) appears to be effective in curing molluscum lesions 3 Orf (contagious pustular dermatitis, or ecthyma contagiosa) and paravaccinia (milker s nodules) are occupational diseases acquired by contact with sheep and cattle, respectively 4 Monkeypox, first identified in 1970, is enzootic in the rain forests of equatorial Africa and presents in humans as a syndrome similar to smallpox The incubation period is about 12 days, and limited person-to-person spread occurs African mortality rates vary from 3% to 11% depending on the immune status of the patient Secondary attack rates appear to be about 10% The first community-acquired outbreak in the United States of monkeypox occurred in 2003 in Wisconsin and other states of the upper Midwest The source appeared to be imported Gambian giant rats via consequent exposure of prairie dogs Clinical findings included a prodrome of fever and chills, headaches, myalgias, and sweats About one-third of patients reported a nonproductive cough After 1 10 days, a maculopapular rash appeared that progressed through stages of vesiculation, pustulation, umbilication, and crusting and in some cases ulceration The rash started on the head, trunk, and extremities, with occasional satellite lesions on the palms, soles, and extremities, and in some cases became generalized Confusion of this clinical presentation with smallpox and varicella occurs, but lymphadenopathy is commonly seen (up to 90% of unvaccinated persons) in only monkeypox, and skin lesions of the palms and soles are frequently seen in these poxviruses but not in varicella infection Susceptible animals include nonhuman primates, rabbits, and rodents Contact with these species is the primary means of transmission to humans General precautions that should.
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