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Pediculosis is a parasitic infestation of the skin of the scalp, trunk, or pubic areas Body lice usually occur among people who live in overcrowded dwellings with inadequate hygiene facilities Pubic lice may be sexually transmitted Head lice may be transmitted by shared use of hats or combs Adults contacting children with head lice frequently acquire the infestation There are three different varieties: (1) pediculosis pubis, caused by Phthirus pubis (pubic louse, crabs ); (2) pediculosis corporis, caused by Pediculus humanus var corporis (body louse); and (3) pediculosis capitis, caused by Pediculus humanus var capitis (head louse) Head and body lice are similar in appearance and are 3 4 mm long The body louse can seldom be found on the body, because the insect comes onto the skin only to feed and must be looked for in the seams of the clothing Trench fever, relapsing fever, and typhus are transmitted by the body louse in countries where those diseases are endemic

Localized rash with pruritus Furuncle-like lesions containing live arthropods Tender erythematous patches that migrate ( larva migrans ) Generalized urticaria or erythema multiforme in some patients

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Some arthropods (eg, mosquitoes and biting flies) are readily detected as they bite Many others are not, eg, because they are too small, because there is no immediate reaction, or because they bite during sleep Reactions are allergic and may be delayed for hours Patients are most apt to consult a clinician when the lesions are multiple and pruritus is intense Many persons will react severely only to their earliest contacts with an arthropod, thus presenting pruritic lesions when traveling, moving into new quarters, etc Body lice, fleas, bedbugs, and mosquitoes should be considered Spiders are often incorrectly believed to be the source of bites; they rarely attack humans, though the brown spider (Loxosceles laeta, Loxosceles reclusa) may cause severe necrotic reactions and death due to intravascular hemolysis, and the black widow spider (Latrodectus mactans) may cause severe systemic symptoms and death (See also 38) In addition to arthropod bites, the most common lesions are venomous stings (wasps, hornets, bees, ants, scorpions) or bites (centipedes), furuncle-like lesions due to fly maggots or sand fleas in the skin, and a linear creeping eruption due to a migrating larva

Infection of monocyte or granulocyte by tick-borne gram-negative bacteria Nine-day incubation period, with variable clinical illness, ranging from asymptomatic to persistent or life-threatening Common symptoms are malaise, nausea, fever, and headaches Excellent response to therapy with tetracyclines

3 Tick Typhus (Rickettsial Fever)

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The term tick typhus denotes a variety of spotted rickettsial fevers They are often named by geography, eg, Mediterranean spotted fever, Queensland tick typhus, Oriental spotted fever, African tick bite fever, Siberian tick typhus, North Asian tick typhus, or by morphology, eg, boutonneuse fever These illnesses are transmitted by tick vectors of the rickettsial organisms R conorii, R australis, R japonica, R africae, and R sibirica (Table 32 3) Dogs and wild animals, usually rodents but even reptiles, may serve as reservoirs The pathogens usually produce an eschar or black spot (tache noire) at the site of the tick bite that may be useful in diagnosis, though spotless boutonneuse fever occurs Symptoms include fever, headache, myalgias, and rash Rarely, papulovesicular lesions may resemble rickettsialpox Endothelial injury produces perivascular edema and dermal necrosis Regional adenopathy, disseminated lesions, renal failure, and focal hepatic necrosis may occur Diabetes, dehydration, and uremia were risk factors for mortality in one series The disease occurs among travelers, the most common travel-associated rick-

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Ehrlichiosis and its analogous disease anaplasmosis present as two clinical entities involving either the monocyte or the granulocyte Human monocytic ehrlichiosis is caused by Ehrlichia chaffeensis and by Ehrlichia canis (Table 32 3) Human granulocytic ehrlichiosis (anaplasmosis) is caused by Anasplasma phagocytophilium and Ehrlichia ewingii Another rickettsia-like organism, Neorickettsia sennetsu, is the etiologic agent of sennetsu fever, which appears to be confined to western Japan

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