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Note the similarity between equations 428 and 430 The left-hand side of both equations is identical, except for the independent variable, while the right-hand side takes a slightly different form The solution of either equation is suf cient, however, to determine all voltages and currents in the circuit Forced Response of Circuits Excited by Sinusoidal Sources Consider again the circuit of Figure 425, where now the external source produces a sinusoidal voltage, described by the expression vS (t) = V cos( t) (431)

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Substituting the expression V cos( t) in place of the source voltage, vS (t), in the differential equation obtained earlier (equation 430), we obtain the following differential equation: d 1 1 vC + vC = V cos t dt RC RC (432)

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Crossing over is known to occur in somatic cells as well as during meiosis It apparently occurs when two homologous chromatids come to lie next to each other and breakage and reunion follow, most likely as a consequence of DNA repair (see chapter 12) Unlike in meiosis, no synaptonemal complex forms The occurrence of mitotic crossing over is relatively rare In the fungus Aspergillus nidulans, mitotic crossing over occurs about once in every one hundred cell divisions Mitotic recombination was discovered in 1936 by Curt Stern, who noticed the occurrence of twin spots in fruit ies that were dihybrid for the yellow allele for body color (y) and the singed allele (sn) for bristle morphology ( g 625) A twin spot could be explained by mitotic crossing over between the sn locus and its centromere ( g 626).

Since the forcing function is a sinusoid, the solution may also be assumed to be of the same form An expression for vC (t) is then the following: vC (t) = A sin t + B cos t which is equivalent to vC (t) = C cos( t + ) (434) (433)

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(b) (a) Fig 235: (a) A diamond coated carbide insert with a tool holder and (b) a polycrystalline diamond tipped insert in the tool holder [41]

Substituting equation 433 in the differential equation for vC (t) and solving for the coef cients A and B yields the expression A cos t B sin t + = 1 V cos t RC 1 (A sin t + B cos t) RC

A crossover in the sn y region would produce only a yellow spot, whereas a double crossover, one between y and sn and the other between sn and the centromere, would produce only a singed spot (Verify this for yourself) These three phenotypes were found in the relative frequencies expected That is, given that the gene locations are drawn to scale in gure 626, we would expect double spots to be most common, followed by yellow spots, with singed spots rarest of all because they require a double crossover This in fact occurred, and no other obvious explanation was consistent with these facts Mitotic crossing over has been used in fungal genetics as a supplemental, or even a primary, method for determining linkage relations Although gene orders are consistent between mitotic and meiotic mapping, relative distances are usually not, which is not totally unexpected.

(435)

We know that neither meiotic nor mitotic crossing over is uniform along a chromosome Apparently, the factors that cause deviation from uniformity differ in the two processes..

and if the coef cients of like terms are grouped, the following equation is obtained: B V A B sin t + A + RC RC RC cos t = 0 (436)

The coef cients of sin t and cos t must both be identically zero in order for equation 436 to hold Thus, A B = 0 RC and A + B V =0 RC RC (437)

Curt Stern (1902 1981)

(a) rake angle [41]

The unknown coef cients, A and B, may now be determined by solving equation 437, to obtain: A= B= V RC 1 + 2 (RC)2 V 1 + 2 (RC)2 V RC V sin t + cos t 2 (RC)2 1+ 1 + 2 (RC)2

(438)

(Courtesy of the Science Council of Japan.)

Thus, the solution for vC (t) may be written as follows: vC (t) = (439)

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