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father method appears in gure 6.27. In this example, a grandfather has one of the traits in question (here, color blindness). We then nd that he has a grandson who is glucose-6-phosphate dehydrogenase (G-6-PD) de cient. From this we can infer that the mother (of the grandson) was dihybrid for the two alleles in the trans con guration. That is, she received her color-blindness allele on one of her X chromosomes from her father, and she must have received the G-6-PD-de ciency allele on the other X chromosome from her mother (why ). Thus, the two sons on the left in gure 6.27 are nonrecombinant, and the two on the right are recombinant. Theoretically, we can determine map distance by simply totaling the recombinant grandsons and dividing by the total number of grandsons. Of course, the methodology would be the same if the grandfather were both color-blind and G-6-PD de cient. The mother would then be dihybrid in the cis con guration, and the sons would be tabulated in the reverse manner. The point is that the grandfather s pheno-

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411 Show that the solution to either equation 428 or equation 430 is suf cient to compute all of the currents and voltages in the circuit of Figure 425 412 Show that the equality

A sin t + B cos t = C cos( t + ) holds if A = C sin B = C cos or, conversely, if C= A2 + B 2 A B

Fig 238: Working drawing of a diamond precision turning tool [42]

type gives us information that allows us to infer that the mother was dihybrid, as well as telling us the cis-trans arrangement of her alleles. We can then score her sons as either recombinant or nonrecombinant.

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In this section, we introduce an ef cient notation to make it possible to represent sinusoidal signals as complex numbers, and to eliminate the need for solving differential equations The student who needs a brief review of complex algebra will nd a reasonably complete treatment in Appendix A, including solved examples and Check Your Understanding exercises For the remainder of the chapter, it will be assumed that you are familiar with both the rectangular and the polar forms of complex number coordinates, with the conversion between these two forms, and with the basic operations of addition, subtraction, multiplication, and division of complex numbers Euler s Identity Named after the Swiss mathematician Leonhard Euler (the last name is pronounced Oiler ), Euler s identity forms the basis of phasor notation Simply stated, the identity de nes the complex exponential ej as a point in the complex plane, which may be represented by real and imaginary components: ej = cos + j sin (440)

Figure 427 illustrates how the complex exponential may be visualized as a point (or vector, if referenced to the origin) in the complex plane Note immediately that the magnitude of ej is equal to 1:

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Grandfather method of determining crossing over between loci on the human X chromosome. G-6-PD is glucose-6-phosphate dehydrogenase.

sin _1

The McGraw Hill Companies, 2001

(441)

Grinding sequence and directions [42]

(442)

From this we can see that it is relatively easy to map the X chromosome. The autosomes are another story. Since there are twenty-two autosomal linkage groups (twentytwo pairs of nonsex chromosomes), it is virtually impossible to determine from simple pedigrees which chromosome two loci are located on. Pedigrees can tell us if two loci are linked to each other, but not on which chromosome. In gure 6.28, the nail-patella syndrome includes, among other things, abnormal nail growth coupled with the absence or underdevelopment of kneecaps. It is a dominant trait.The male in generation II is dihybrid, with the A allele of the ABO blood type system associated with the nail-patella allele (NPS1) and the B allele with the normal nail-patella allele (nps1). Thus only one child in eight (III-5) is recombinant. Actually, the map distance is about 10%. In general, map distances appear greater in females than in males because more crossing over occurs in females (box 6.3). We now turn our attention to the localization of loci to particular human chromosomes. The rst locus that was de nitely established to be on a particular autosome was the Duffy blood group on chromosome 1. This was ascertained in 1968 from a family that had a morphologically odd, or uncoiled, chromosome 1. Inheritance in the Duffy blood group system followed the pattern of inheritance of the uncoiled chromosome. Real strides have been made since then. Two techniques, chromosomal banding and somatic-cell hybridization, have been crucial to autosomal mapping.

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