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input amplitudes of the other. The SSPA nonlinearity also determines the IM power level. In the next section we will discuss a method that can be used to find SSPA parameters that quantify the nonlinearity. 13.6.1 Estimation of SSPA Parameters from IM Data From (13.14) (13.17) we notice that the parameters A and C play major roles in carrier amplification and IM power generation; thus it is important to estimate these two parameters. The ratio between A and C can be determined from the carrier and IM amplitudes given in (13.14) and (13.16). The carrier-to-IM-amplitude ratio is obtained as C1 A + 0 75CP 2 + 1 5CQ2 = 0 75CQ2 I1 (13.18)
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that an unusual functional group called a cyanoguanidine had very similar physiochemical properties to a thiourea. Replacement of this latter group in metiamide by the cyanoguanidine function gave cimetidine, the potent orally active drug that for the rst time allowed pharmacological treatment of gastric ulcers (Fig. 9). The drug was also safe enough to nd broad use in the treatment of acid re ux. An unveri able account holds that the trade name Tagametw for cimetidine derives from the fact that the compound was supposedly being groomed as a follow-on successor to metiamide: thus Tag along Metiamide. New research programs at both Smith Kline and competitive laboratories were not long in exploring the breadth of the structural requirements for histamine H2 blockers. Chemists at Bristol Laboratories found that one of the hydrogens on the methyl groups of the cyanoguanidine could be replaced by an acetylene function (Fig. 10). Although this agent, etintidine,26 is a potent histamine H2 blocker, it is apparently not used clinically. A more profound change from work at the lab that rst produced cimetidine involved replacement of the cyanoguanidine function by a complex heterocycle. It is of note that the aminopyridone at the end of the side chain in oxmetidine27 incorporates a good part of the guanidine function in cyclized form. In a further demonstration of the looseness of structural requirement, chemists at Allen and Hanbury s were able to replace the ve-membered imidazole ring that had descended from histamine itself by a ve-membered, oxygen-containing furan ring. The basic nitrogen present in the original ring structure was carried on a carbon
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